More about Cosmetic injections and the science behind Striagen-SD®
When injected into the face this neurotoxin inactivates the neuromuscular junction, thereby locally paralyzing muscle contraction. When injected at appropriate locations on the face, this toxin inhibits contraction of facial muscles, preventing the appearance and imprinting of "dynamic wrinkles" or "expression lines". This treatment offers an effective and immediate anti-wrinkle solution, yet hardly falls within the definition of a cosmetic product. Such a drastic procedure is at odds with trends in modern society, wherein consumers increasingly favor the use of natural, plant-derived ingredients. Furthermore, many consumers are squeamish about the prospect of having any substance, let alone a neurotoxin, injected in their faces. This apprehension is heightened by potential side effects; when applied at inappropriate levels or locations, botulic toxin injections can temporarily cause sagging eyelid muscles (ptosis). Moreover, the long-term impact of continued of these injections is not known.
Why is Striagen-SD® a safe and effective alternative to restoring youthful skin?
One of the key ingredients in Striagen-DS is Matrixyl 3000®. Matrixyl 3000® was designed to promote collagen production while strengthening the essential structure of skin tissue. Matrixyl 3000 remarkably encourages skin tissue to restore itself to a more youthful strength while promoting deep tissue repair. When skin is wrinkled, tiny cells called fibroblasts help to repair the damaged area by forming new tissue. Part of the fibroblasts job is to produce new collagen, an essential component of connective tissue. Although your fibroblasts never completely lose their ability to create more collagen, with age your levels dwindle and your skin dries out and wrinkles. Matrixyl 3000 stimulates fibroblast molecules in the skin, enabling them to significantly reduce the appearance of wrinkles.
In a clinical trial, Matrixyl® 3000 achieved the following results:
- 33% decrease in wrinkle density
- 23% decrease in the volume of wrinkles
- 20% decrease in the depth of wrinkles
The proven benefits are:
- A reduction in the appearance of wrinkle volume and depth
- A reduction in the appearance of roughness and complexity
- A decrease in the area around wrinkles and the appearance of wrinkle density
Argireline® delivers superior anti-wrinkle results. It is a combination of amino acids formulated to relax facial wrinkles, reduce the degree of existing wrinkles, and stop their future development.
Argireline® represents a breakthrough in cosmetic science because of its remarkable speed in anti-wrinkle activity. It has been shown to produce noticeable results in as little as 30 days of steady applications.
Skin treated for 30 days with Argireline® based cream
You can see that the depth of the wrinkle has significantly decreased after 30 days of treatment.
Pepha-Tight: PEPHA®-TIGHT is a highly purified biotechnologically produced extract from the microalga Nannochloropsis oculata combined with a well balanced fraction of polysaccharides. A special fermentation technology and optimal growth con- ditions ensure the high quality and pureness of the algae extract. PEPHA®-TIGHT protects human fibroblasts from oxidative stress provoked by hydrogen peroxide.
PEPHA®-TIGHT tightens the skin immediately and has in parallel a long term effect strengthening the skin's connective tissue. Loose skin often is a result of oxidative stress and damaged collagen fibres. As shown in in vitroassays PEPHA®- TIGHT protects skin cells from oxidative stress and increases simultaneously the formation of collagen-I.2. PEPHA®-TIGHTstimulates the formation of collagen-I.
Function:
- Has noticeable instant tightening effect and smoothes fine wrinkles
- Acts preventively as a protection shield against oxidative stress
- Strengthens the connective tissue by increasing the formation of collagen-I
When applied externally, this newly developed active agent MYOXINOL leads to a gentle immobilization of the facial muscles, without completely laming the muscles. The features look relaxed and the facial expressions are not impaired.
Function:
- Concentrated care for the treatment of fine lines and wrinkles on the forehead, in the eye area and around the nose and mouth.
- Myoxinol relaxes the facial features and smoothens the expression lines without invasive operations.
- The active agent from hibiscus esculentus decelerates the process of biological skin ageing by its cell-protecting (antioxidant) effects.
- The collagen biomatrix calms the skin and balances out the complexion.
Proven Effects:
To prove the efficiency a test model was selected by cultivating muscle and nerve cells together. The effect of MYOXINOL was measured over 24 hours and a significant of muscle cell contractions was observed at the end of this time. Thus Myoxinol® combats the most important mechanical reasons for the development of expression line.
As its activity is not limited to relieving the mechanical formation of wrinkles, Myoxinol® offers more cosmetic anti-ageing benefits than botulic toxin injections. The anti-free radical/antioxidant activity of Myoxinol® also slows extrinsic biological ageing of cells and dermal macro-molecules, preserving skin's elasticity and delivering long term anti-ageing benefits.
There are two main categories of wrinkle formation mechanisms in skin: biological (ageing of cells, oxidation or glycation of macromolecules and mechanical (i.e. when face muscles are involved). The cosmetics industry has been addressing biological parameters for a long time: antioxidant systems, cell metabolism boosters, anti-glycation actives - all aiming at preserving skin's elasticity, and protecting it from chronological and environmental ageing. The mechanical stresses involved in skin ageing, e.g. facial muscle contraction, used to be treated in beauty salons via specific massage techniques. They only lately became the focus of more general attention from customers and the cosmetic dermatology industry. Facial muscles are responsible for the formation of dynamic wrinkles: horizontal and vertical frown lines across the forehead, crow's foot around the eye and naso-labial lines around the mouth.
As long as the biological ageing mechanisms have not degraded the skin's elasticity, these lines are reversible and the skin recovers its smooth appearance when facial muscles relax. But when biological and mechanical factors work in concert, the skin loses its elasticity and its ability to return to its initial state after muscle contraction. The dynamic wrinkles become permanent, generating "expression" lines.
Botulic toxin injections offer a solution to diminish these mechanical stresses. The active substance in Cosmetic injections is Botulinum Toxin Type A, a protein complex (MW ~ 150 kDa) produced by a strain of Clostridium botulinum, the Gram-positive bacteria responsible for botulism. Injected neurotoxin prevents facial muscle contraction through inhibition of acetylcholine release from the stimulated nerves at the neuro-muscular junction.
These injections require appropriate expertise during treatment and are perceived by many as risky because of the toxicity of the molecule. Thus, their routine administration for cosmetic purposes is not authorized by all local regulations. Moreover, even where the procedure is approved some customers remain deterred by the severity of the procedure and its potential side effects.
For these reasons, there is growing market interest in alternatives to botulic toxin injections. Not mentioning the needle-shy ones, many consumers seek a topical cosmetic alternative, preferably one offering a mechanism of action that addresses wrinkles formed by facial muscles. Additionally, among those who undergo botulic toxin treatments, many seek cosmetic products that will extend the time between treatments.
Myoxinol®, a natural complex of oligopeptides obtained from the seeds of Hibiscus esculentus, offers more than just wrinkle reduction. In addition to inhibition of muscle cell contraction, demonstrated with an innovative in vitro model, Myoxinol® also protects cells and dermal macromolecules from oxidative stress. Myoxinol® is a comprehensive, patented anti-ageing active, suitable for a gentle topical treatment, effective against both mechanical and biological modes of wrinkle formation.
The anti-wrinkle activity of Myoxinol® is demonstrated by these clinical results: a 26% reduction of wrinkle depth (mean value versus placebo) after a 3-week treatment by topical applications of an emulsion containing 1% Myoxinol®. This further confirms the bioavailabilty of Myoxinol®, which was already suggested by its molecular weight distribution (predominance of low molecular weight oligopeptides).
Source from Newton-Everett Cosmeceuticals®
