10 mg, 25 mg and 50 mg Tablets
Pregnenolone is the starting point from which all steroid hormones are manufactured
in our bodies. Its conversion in the body follows different pathways, depending
on individual needs. Several clinical studies have demonstrated that pregnenolone
may enhance psychomotor performance and decrease fatigue in healthy subjects.
Pregnenolone - The Balancing Hormone
Pregnenolone - a hormone produced from cholesterol in our adrenal glands, liver,
skin, testicles, ovaries, and brain - was the subject of intense interest in
the 1940's. Some of the earliest studies, performed by well-known researcher
Hans Selye, found it to be helpful in reducing stress and fatigue.
Additional studies were conducted throughout the decade, with positive results.
Pregnenolone supplementation was found to benefit people who were under excessive
stress. It also was reported to support joint and tissue function and to contribute
to skin elasticity.
Pregnenolone is believed to affect stress levels through its influence on the
adrenal glands, which produce more steroid hormones when people are under stress.
Pregnenolone may also affect brain chemistry in beneficial ways. It has been
found to inhibit the GABA receptors in brain cells - which may result in increased
mental alertness. It may also stimulate the NMDA (N-methyl-D-aspartate) receptors,
which play an important role in regulating synapses, thus influencing learning
Pregnenolone - The Unique Hormone
Much of the current interest in pregnenolone is related to its role as "the
grandmother of all steroid hormones". Pregnenolone is the starting point
from which all steroid hormones are manufactured in our bodies. As a "hormone
balancer", it has the capacity to increase the levels of steroid hormones
that are deficient in our bodies and to reduce the levels of excess circulating
hormones. Some scientists believe pregnenolone is converted into other hormones
only as they are needed by our bodies.
The conversion of pregnenolone follows different pathways, depending upon cellular
requirements. Pregnenolone may be converted into DHEA (dehydroepiandrosterone),
which in turn can be changed into androgens (including testosterone), estrogens
and other steroids; or, it may be converted into any or all of a chain of hormones
including progesterone, corticosterone, and aldosterone.
These characteristics make pregnenolone unique. Because cells may only convert
pregnenolone into other hormones on an "as needed" basis, pregnenolone
may correct imbalances in the levels of some hormones, without affecting others.
This is a great advantage over steroid hormones like DHEA, which may create
excess estrogen and testosterone.
Pregnenolone is also distinctive because of the innumerable bodily activities
it can influence. As a steroid hormone precursor, it is believed to be involved
in every biochemical action exhibited by any steroid hormone. This means it
may impact memory, mental alertness, stress responses, female reproductive cycles,
the body's natural defenses, and joint and tissue function. With such a wide
spectrum of involvement, the potential uses of pregnenolone could be boundless.
Source Naturals Pregnenolone is available in 10 mg sublinguals and tablets,
as well as in 25 mg tablets. All potencies are sold in 60 and 120 tablet bottles.
Supplement Facts for 25 mg
Serving Size: 1 tablet
Vitamin C (as ascorbyl palmitate) 11 mg 0.18
Pregnenolone 25 mg
Other Ingredients: dibasic calcium phosphate, microcrystalline cellulose, sorbitol,
stearic acid, colloidal silicon dioxide and magnesium stearate.
Warning: Not for use by persons under 40, or pregnant or breastfeeding women.
Do not take pregnenolone if you have severe benign prostatic hypertrophy, or
hormone-responsive cancer, including estrogen-dependent breast cancer or prostate
cancer. Consult your physician before taking PREG if you have any medical condition
including high blood pressure, diabetes, epilepsy, liver disease or a kidney,
thyroid, adrenal or immune system disorder, or if you are taking any medication
including corticosteroids, asthma medication, calcium channel blockers, benzodiazepines,
barbiturates, anti-anxiety drugs, oral contraceptives, progesterone, progestin
or are on estrogen replacement therapy.
Suggested Use: 1 to 2 Pregnenolone tablets daily, or as recommended
by your physician. One-half pregnenolone tablet may be sufficient for some people.
Do not exceed 50 mg per day. Do not pregnenolone take for more than 30 days
without the advice of your physician, and have your blood hormone (estrogen,
testosterone, DHEA) levels regularly assessed by your physician. Using pregnenolone
(PREG) may elevate your DHEA levels, and DHEA can increase estrogen and testosterone
levels. Read entire label before using Pregnenolone.