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|  | | ENADA NADH 5mg Blister 30 tabs from Source Naturals
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What is NAD or NADH?
NAD is the abbreviation used for the biologically active coenzyme form of vitamin B-3 Niacinamide known as Nicotinamide Adenine Dinucleotide. NAD is the oxidized form of coenzyme B-3 that acts as a hydrogen (H) acceptor while NADH is the reduced form that donates hydrogen in the Kreb's Citric Acid Cycle (KCAC) and Electron Transport Side Chain (ETSC). NADH is a complex molecule comprised of vitamin B-3, ribose, a phosphate group and an adenine nucleotide that can be made in the liver and other cells. NAD and NADH are converted into each other many times along the pathway of these energy cycles. They are both involved in transferring electron pairs or energy sparks during energy-transfer reactions within the cell. As these electron pairs are eventually shuttled from the high-energy donor (NADH) to oxygen to make water, chemical energy in the form of ATP (Adenosine Tri-Phosphate) is produced.
What does NAD or NADH do?
NADH is necessary to oxidize or burn all foods (sugars, fats and amino acids) thus producing Pyruvate from the Glycolytic cycle to power the Kreb's Cycle which produces electron sparks of energy that's used by the Electron Transport side chain to generate ATP energy that in turn powers the cell. In short NAD as a precursor to NADH and vice versa are considered to be important coenzymes needed by the human body to produce the energy necessary to sustain life.
NAD's reduced form NADH has been studied to increase natural dopamine production in Parkinson's patients. It has also been helpful in patients with depression due to its ability to increase the production of dopamine and noradrenaline. Supplementing with NADH also may spare tryptophan in the body from being utilized as a precursor for NADH production thus making this important amino acid available for the production of a much needed neurotransmitter known as serotonin. A deficiency in serotonin may cause depression. NADH is the first of five enzyme complexes of the Electron Transport Chain (hence the name Coenzyme), where significant amounts of ATP energy for the body and brain's needs is manufactured. The human brain must produce and use approximately 20% of the bodies ATP energy, therefore a deficiency in NADH and a consequent loss of energy may be implicated in depression, dementia and chronic fatigue disorders. NAD also serves as an activator of other enzymes like alcohol dehydrogenase and acetaldehyde dehydrogenase that are needed to detoxify the alcohol we drink into carbon dioxide and water.
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